The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has resulted in a global health and economic crisis of unprecedented scale. The high transmissibility of SARS- CoV-2, combined with a lack of population immunity and prevalence of severe clinical outcomes, urges the rapid development of effective therapeutic counter measures. To combat this pandemic and in keeping with its mission and vision, the U.S.–India Science & Technology Endowment Fund (USISTEF) announced a call for proposals under the category of COVID-19 Ignition Grants in April 2020. After a rigorous binational review process, USISTEF announced awards to 11 bilateral teams, proposing out-of-the-box, innovative ideas that address the COVID-19 challenge.